Our new Very clear+ tissue clearing procedure is the only real method that delipidates samples with no change in morphology and with minimum effect on structural integrity.
Megatome is actually a vibrating microtome created to part a wide range of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With higher blade vibrating frequency and minimized blade deflection, Megatome enables substantial-throughput tissue sectioning with uniform area profile, and minimal tissue damage and information loss.
Antibodies may take weeks to diffuse through only a few millimeters of tissue, with a steep labeling gradient from surface to Main.
Megatome is designed for accuracy: the blade vibrates at the next frequency and larger amplitude vary than other microtomes, and contains a exclusive deflection Regulate mechanism.
SE uses a rotational electric industry to disperse highly electromobile molecules (like antibodies or surfactant micelles) through a porous sample devoid of damaging electrically billed structures inside the tissue. This allows two-four day clearing of intact organs,
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It’s time and energy to upgrade your microtome to Megatome. With precise higher-frequency slicing for an unmatched number of sample measurements and kinds – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized megatomi.com for various purposes.
The SmartSPIM mild sheet microscope provides unparalleled resolution and acquisition pace throughout intact tissue volumes, even though its modular design means that you can improve and customize unique elements.
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Defend avoids the variability of hydrogel embedding and the data loss from PFA preservation, defending specimens for many rounds of processing.
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